Version 5.4
Homo sapiens Gene: PCDH8
Summary
InnateDB Gene IDBG-36060.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCDH8
Gene Name protocadherin 8
Synonyms ARCADLIN; PAPC
Species Homo sapiens
Ensembl Gene ENSG00000136099
Encoded Proteins
IDBP-36062
protocadherin 8
IDBP-36064
protocadherin 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:52842889-52848641
Strand Reverse strand
Band q14.3
Transcripts
ENST00000377942 ENSP00000367177
ENST00000338862 ENSP00000341350
ENST00000613548
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0001756 somitogenesis
GO:0007156 homophilic cell adhesion
GO:0007267 cell-cell signaling
GO:0007268 synaptic transmission
GO:0016331 morphogenesis of embryonic epithelium
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0030054 cell junction
GO:0030425 dendrite
GO:0042734 presynaptic membrane
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036422
View Gene Order
ENSBTAG00000018179
Not yet available
Cross-References
SwissProt O95206
TrEMBL A0A024QZ94
UniProt Splice Variant
Entrez Gene 5100
UniGene Hs.19492
RefSeq NM_032949 NM_002590
HUGO HGNC:8660
OMIM 603580
CCDS CCDS9439 CCDS9438
HPRD 04660
IMGT
EMBL AF061573 AK297652 AL139085 AY013873 BC036025 CH471124
GenPept AAC70009 AAH36025 AAK21986 BAG60019 CAI14110 CAI14111 EAW52049 EAW52050 EAW52051
RNA Seq Atlas 5100

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca