InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PCDH8

Summary

InnateDB Protein

IDBP-36062.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCDH8

Protein Name

protocadherin 8

Synonyms

ARCADLIN; PAPC;

Species

Homo sapiens

Ensembl Protein

ENSP00000367177

InnateDB Gene

IDBG-36060 (PCDH8)

Protein Structure

UniProt Annotation

Function

Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane. Note=Also expressed in neuronal cell bodies. Localized to excitatory, but not with inhibitory, synapses. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding

Biological Process

GO:0001756	somitogenesis
GO:0007156	homophilic cell adhesion
GO:0007267	cell-cell signaling
GO:0007268	synaptic transmission
GO:0016331	morphogenesis of embryonic epithelium

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0042734	presynaptic membrane
GO:0045211	postsynaptic membrane