Version 5.4
Homo sapiens Gene: FBXL8
Summary
InnateDB Gene IDBG-36065.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXL8
Gene Name F-box and leucine-rich repeat protein 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135722
Encoded Proteins
IDBP-36067
F-box and leucine-rich repeat protein 8
IDBP-749994
IDBP-483444
F-box and leucine-rich repeat protein 8
IDBP-478019
F-box and leucine-rich repeat protein 8
IDBP-474025
F-box and leucine-rich repeat protein 8
IDBP-476924
F-box and leucine-rich repeat protein 8
IDBP-479316
F-box and leucine-rich repeat protein 8
IDBP-476063
F-box and leucine-rich repeat protein 8
IDBP-809069
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:67159931-67164570
Strand Forward strand
Band q22.1
Transcripts
ENST00000258200 ENSP00000258200
ENST00000518148 ENSP00000464169
ENST00000519945 ENSP00000429684
ENST00000519917 ENSP00000430490
ENST00000517382 ENSP00000430745
ENST00000521920 ENSP00000427895
ENST00000523893 ENSP00000428379
ENST00000519378 ENSP00000430027
ENST00000518753 ENSP00000476658
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033313
View Gene Order
ENSBTAG00000023632
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.710714
RefSeq NM_018378
HUGO
OMIM
CCDS CCDS10831
HPRD 16430
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca