Version 5.4
Homo sapiens Gene: RARG
Summary
InnateDB Gene IDBG-36147.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RARG
Gene Name retinoic acid receptor, gamma
Synonyms NR1B3; RARC
Species Homo sapiens
Ensembl Gene ENSG00000172819
Encoded Proteins
IDBP-36151
retinoic acid receptor, gamma
IDBP-241614
retinoic acid receptor, gamma
IDBP-376177
retinoic acid receptor, gamma
IDBP-596405
retinoic acid receptor, gamma
IDBP-717452
IDBP-717299
IDBP-718269
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:53210567-53232980
Strand Reverse strand
Band q13.13
Transcripts
ENST00000338561 ENSP00000343698
ENST00000394426 ENSP00000377947
ENST00000425354 ENSP00000388510
ENST00000543726 ENSP00000444335
ENST00000543762
ENST00000550265
ENST00000548317
ENST00000551580
ENST00000548284
ENST00000546717 ENSP00000454417
ENST00000551158 ENSP00000454604
ENST00000550362 ENSP00000454385
ENST00000550721
ENST00000550350
ENST00000551501
ENST00000546377
ENST00000549859
ENST00000552901
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 37 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003708 retinoic acid receptor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0046965 retinoid X receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001843 neural tube closure
GO:0002063 chondrocyte development
GO:0002068 glandular epithelial cell development
GO:0003406 retinal pigment epithelium development
GO:0003417 growth plate cartilage development
GO:0003430 growth plate cartilage chondrocyte growth
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008361 regulation of cell size
GO:0009952 anterior/posterior pattern specification
GO:0010467 gene expression
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0031076 embryonic camera-type eye development
GO:0031641 regulation of myelination
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032526 response to retinoic acid
GO:0035116 embryonic hindlimb morphogenesis
GO:0035264 multicellular organism growth
GO:0043010 camera-type eye development
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043068 positive regulation of programmed cell death
GO:0043401 steroid hormone mediated signaling pathway
GO:0045596 negative regulation of cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048048 embryonic eye morphogenesis
GO:0048384 retinoic acid receptor signaling pathway
GO:0048608 reproductive structure development
GO:0048732 gland development
GO:0060041 retina development in camera-type eye
GO:0060070 canonical Wnt signaling pathway
GO:0060173 limb development
GO:0060324 face development
GO:0060348 bone development
GO:0060349 bone morphogenesis
GO:0060429 epithelium development
GO:0060534 trachea cartilage development
GO:0060740 prostate gland epithelium morphogenesis
GO:0061037 negative regulation of cartilage development
GO:0070384 Harderian gland development
GO:0071300 cellular response to retinoic acid
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001288
View Gene Order
ENSBTAG00000007592
Not yet available
Pathways
NETPATH
REACTOME
REACT_15525
Nuclear Receptor transcription pathway pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
retinoic_acid_pathway
Retinoic acid receptors-mediated signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.1497
RefSeq NM_000966 NM_001042728 NM_001243730 NM_001243731 NM_001243732 XM_005269056 XM_005269057
HUGO
OMIM
CCDS CCDS41790 CCDS58236 CCDS58237 CCDS8850
HPRD 01573
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca