InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RARG

Summary

InnateDB Protein

IDBP-596405.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RARG

Protein Name

retinoic acid receptor, gamma

Synonyms

NR1B3; RARC;

Species

Homo sapiens

Ensembl Protein

ENSP00000444335

InnateDB Gene

IDBG-36147 (RARG)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0046965	retinoid X receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0008285	negative regulation of cell proliferation
GO:0008361	regulation of cell size
GO:0010467	gene expression
GO:0032526	response to retinoic acid
GO:0035116	embryonic hindlimb morphogenesis
GO:0043065	positive regulation of apoptotic process
GO:0043068	positive regulation of programmed cell death
GO:0043401	steroid hormone mediated signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048048	embryonic eye morphogenesis
GO:0048384	retinoic acid receptor signaling pathway
GO:0060070	canonical Wnt signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000003 Retinoid X receptor/HNF4
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003070 Orphan nuclear receptor
IPR003078 Retinoic acid receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00545
PR00047
PR00398
PR01284
PR01292

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt