Version 5.4
Homo sapiens Gene: TG
Summary
InnateDB Gene IDBG-36157.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TG
Gene Name thyroglobulin
Synonyms AITD3; TGN
Species Homo sapiens
Ensembl Gene ENSG00000042832
Encoded Proteins
IDBP-36159
thyroglobulin
IDBP-474151
thyroglobulin
IDBP-481582
thyroglobulin
IDBP-482982
thyroglobulin
IDBP-483247
thyroglobulin
IDBP-481987
thyroglobulin
IDBP-477175
thyroglobulin
IDBP-483691
thyroglobulin
IDBP-475238
thyroglobulin
IDBP-477289
thyroglobulin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:132866958-133134903
Strand Forward strand
Band q24.22
Transcripts
ENST00000220616 ENSP00000220616
ENST00000523901 ENSP00000427871
ENST00000520769
ENST00000523756 ENSP00000428628
ENST00000518097
ENST00000518505 ENSP00000429605
ENST00000519178 ENSP00000430523
ENST00000518058 ENSP00000429164
ENST00000519543 ENSP00000430430
ENST00000520197
ENST00000520089
ENST00000519294
ENST00000524151
ENST00000522523
ENST00000522797 ENSP00000430087
ENST00000518108 ENSP00000429761
ENST00000522996
ENST00000522809
ENST00000521107 ENSP00000430161
ENST00000522691
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
Biological Process
GO:0006590 thyroid hormone generation
GO:0007165 signal transduction
GO:0015705 iodide transport
GO:0030878 thyroid gland development
GO:0031641 regulation of myelination
GO:0042403 thyroid hormone metabolic process
GO:0042446 hormone biosynthetic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053469
View Gene Order
ENSBTAG00000007823
Not yet available
Pathways
NETPATH
NetPath_23
TSH pathway
REACTOME
KEGG
hsa05320
Autoimmune thyroid disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654591
RefSeq NM_003235 XM_005251042 XM_005251043 XM_006716623
HUGO
OMIM
CCDS CCDS34944
HPRD 01782
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca