Version 5.4
Homo sapiens Gene: TSSK4
Summary
InnateDB Gene IDBG-3658.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSSK4
Gene Name testis-specific serine kinase 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000139908
Encoded Proteins
IDBP-3660
testis-specific serine kinase 4
IDBP-3662
testis-specific serine kinase 4
IDBP-363834
testis-specific serine kinase 4
IDBP-588414
testis-specific serine kinase 4
IDBP-602577
testis-specific serine kinase 4
IDBP-589313
testis-specific serine kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:24205697-24208362
Strand Forward strand
Band q12
Transcripts
ENST00000339917 ENSP00000339179
ENST00000287913 ENSP00000287913
ENST00000428351 ENSP00000412180
ENST00000554420
ENST00000556621 ENSP00000452054
ENST00000555092 ENSP00000451121
ENST00000553766 ENSP00000450752
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
GO:0032793 positive regulation of CREB transcription factor activity
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000007591
View Gene Order
ENSBTAG00000002710
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001184739 NM_174944
HUGO
OMIM
CCDS CCDS53890 CCDS9618
HPRD 12642
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca