InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TSSK4

Summary

InnateDB Protein

IDBP-3660.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TSSK4

Protein Name

testis-specific serine kinase 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000339179

InnateDB Gene

IDBG-3658 (TSSK4)

Protein Structure

UniProt Annotation

Function

May be involved in a signaling pathway during male germ cell development or mature sperm function (By similarity). Phosphorylates CREB1 on Ser-133 and stimulates downstream signaling. {ECO:0000250, ECO:0000269PubMed:15964553}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed only in the testis. {ECO:0000269PubMed:15964553}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030154	cell differentiation
GO:0032793	positive regulation of CREB transcription factor activity

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt