Version 5.4
Homo sapiens Gene: UNC119
Summary
InnateDB Gene IDBG-36803.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UNC119
Gene Name unc-119 homolog (C. elegans)
Synonyms HRG4; IMD13; POC7; POC7A
Species Homo sapiens
Ensembl Gene ENSG00000109103
Encoded Proteins
IDBP-36805
unc-119 homolog (C. elegans)
IDBP-36807
unc-119 homolog (C. elegans)
IDBP-373534
unc-119 homolog (C. elegans)
IDBP-764839
IDBP-760794
IDBP-762624
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:28546707-28552668
Strand Reverse strand
Band q11.2
Transcripts
ENST00000335765 ENSP00000337040
ENST00000301032 ENSP00000301032
ENST00000444148 ENSP00000414639
ENST00000484980 ENSP00000466831
ENST00000470125 ENSP00000465323
ENST00000487844
ENST00000578434
ENST00000581945 ENSP00000463893
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 118 experimentally validated interaction(s) in this database.
Experimentally validated
Total 118 [view]
Protein-Protein 118 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0007109 cytokinesis, completion of separation
GO:0007268 synaptic transmission
GO:0007601 visual perception
GO:0007602 phototransduction
GO:0042953 lipoprotein transport
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:1900186 negative regulation of clathrin-mediated endocytosis
GO:2001287 negative regulation of caveolin-mediated endocytosis
Cellular Component
GO:0000922 spindle pole
GO:0005813 centrosome
GO:0005829 cytosol
GO:0045171 intercellular bridge
GO:0051233 spindle midzone
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002058
View Gene Order
ENSBTAG00000013096
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
NetPath_17
IL5 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.410455
RefSeq NM_005148 NM_054035
HUGO
OMIM
CCDS CCDS11233 CCDS11234
HPRD 04927
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca