Version 5.4
Homo sapiens Gene: BDNF
Summary
InnateDB Gene IDBG-36817.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BDNF
Gene Name brain-derived neurotrophic factor
Synonyms ANON2; BULN2
Species Homo sapiens
Ensembl Gene ENSG00000176697
Encoded Proteins
IDBP-36819
brain-derived neurotrophic factor
IDBP-36821
brain-derived neurotrophic factor
IDBP-238442
brain-derived neurotrophic factor
IDBP-238444
brain-derived neurotrophic factor
IDBP-238446
brain-derived neurotrophic factor
IDBP-238448
brain-derived neurotrophic factor
IDBP-238450
brain-derived neurotrophic factor
IDBP-369990
brain-derived neurotrophic factor
IDBP-369992
brain-derived neurotrophic factor
IDBP-369993
brain-derived neurotrophic factor
IDBP-369995
brain-derived neurotrophic factor
IDBP-586387
brain-derived neurotrophic factor
IDBP-602790
brain-derived neurotrophic factor
IDBP-583741
brain-derived neurotrophic factor
IDBP-590580
brain-derived neurotrophic factor
IDBP-583177
brain-derived neurotrophic factor
IDBP-603215
brain-derived neurotrophic factor
IDBP-602281
brain-derived neurotrophic factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer\'s and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:27654893-27722058
Strand Reverse strand
Band p14.1
Transcripts
ENST00000314915 ENSP00000320002
ENST00000356660 ENSP00000349084
ENST00000395986 ENSP00000379309
ENST00000395983 ENSP00000379307
ENST00000395981 ENSP00000379305
ENST00000395980 ENSP00000379304
ENST00000395978 ENSP00000379302
ENST00000438929 ENSP00000414303
ENST00000420794 ENSP00000389564
ENST00000418212 ENSP00000400502
ENST00000439476 ENSP00000389345
ENST00000525528 ENSP00000437138
ENST00000533131 ENSP00000432727
ENST00000533246 ENSP00000432376
ENST00000530861 ENSP00000435564
ENST00000530786 ENSP00000433003
ENST00000532997 ENSP00000435805
ENST00000525950 ENSP00000432035
ENST00000584049
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005169 neurotrophin TRKB receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001657 ureteric bud development
GO:0001662 behavioral fear response
GO:0001666 response to hypoxia
GO:0002544 chronic inflammatory response
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0007399 nervous system development
GO:0007406 negative regulation of neuroblast proliferation
GO:0007411 axon guidance
GO:0007412 axon target recognition
GO:0007611 learning or memory
GO:0007612 learning
GO:0007623 circadian rhythm
GO:0007631 feeding behavior
GO:0008038 neuron recognition
GO:0009416 response to light stimulus
GO:0009642 response to light intensity
GO:0009725 response to hormone
GO:0010996 response to auditory stimulus
GO:0014047 glutamate secretion
GO:0014076 response to fluoxetine
GO:0014823 response to activity
GO:0016358 dendrite development
GO:0019222 regulation of metabolic process
GO:0021675 nerve development
GO:0030516 regulation of axon extension
GO:0031667 response to nutrient levels
GO:0032094 response to food
GO:0032229 negative regulation of synaptic transmission, GABAergic
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033189 response to vitamin A
GO:0034612 response to tumor necrosis factor
GO:0035864 response to potassium ion
GO:0042490 mechanoreceptor differentiation
GO:0042493 response to drug
GO:0042596 fear response
GO:0043066 negative regulation of apoptotic process
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045666 positive regulation of neuron differentiation
GO:0045843 negative regulation of striated muscle tissue development
GO:0046668 regulation of retinal cell programmed cell death
GO:0048167 regulation of synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048170 positive regulation of long-term neuronal synaptic plasticity
GO:0048172 regulation of short-term neuronal synaptic plasticity
GO:0048675 axon extension
GO:0048839 inner ear development
GO:0050890 cognition
GO:0051602 response to electrical stimulus
GO:0051965 positive regulation of synapse assembly
GO:0055093 response to hyperoxia
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0060548 negative regulation of cell death
GO:0061193 taste bud development
GO:0071356 cellular response to tumor necrosis factor
GO:0071874 cellular response to norepinephrine stimulus
GO:0072347 response to anesthetic
GO:0097484 dendrite extension
GO:1901215 negative regulation of neuron death
GO:1902065 response to L-glutamate
GO:1990089 response to nerve growth factor
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990138 neuron projection extension
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0008021 synaptic vesicle
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030061 mitochondrial crista
GO:0030424 axon
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043204 perikaryon
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000048482
View Gene Order
ENSBTAG00000008134
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa05016
Huntington's disease pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
p75ntrpathway
p75(NTR)-mediated signaling
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL E9PMP3
UniProt Splice Variant
Entrez Gene 627
UniGene Hs.502182 Hs.678259
RefSeq NM_001143805 NM_001143806 NM_001143807 NM_001143808 NM_001143809 NM_001143810 NM_001143811 NM_001143812 NM_001143813 NM_001143814 NM_001143816 NM_001709 NM_170731 NM_170732 NM_170733 NM_170734 NM_170735
HUGO HGNC:1033
OMIM 113505
CCDS CCDS41628 CCDS44558 CCDS7865 CCDS7866
HPRD 00214
IMGT
EMBL AC103796 AC104563
GenPept
RNA Seq Atlas 627

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca