InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bdnf

Summary

InnateDB Gene

IDBG-195506.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bdnf

Gene Name

brain derived neurotrophic factor

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000048482

Encoded Proteins

IDBP-195508

brain derived neurotrophic factor

IDBP-258940

brain derived neurotrophic factor

IDBP-258942

brain derived neurotrophic factor

IDBP-258944

brain derived neurotrophic factor

IDBP-258946

brain derived neurotrophic factor

IDBP-258948

brain derived neurotrophic factor

IDBP-258950

brain derived neurotrophic factor

IDBP-258952

brain derived neurotrophic factor

IDBP-258954

brain derived neurotrophic factor

IDBP-258956

brain derived neurotrophic factor

IDBP-718548

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176697:
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer\'s and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:109674700-109727007

Strand

Forward strand

Band

Transcripts

ENSMUST00000053317	ENSMUSP00000057989
ENSMUST00000111051	ENSMUSP00000106680
ENSMUST00000111050	ENSMUSP00000106679
ENSMUST00000111049	ENSMUSP00000106678
ENSMUST00000111047	ENSMUSP00000106676
ENSMUST00000111046	ENSMUSP00000106675
ENSMUST00000111045	ENSMUSP00000106674
ENSMUST00000111044	ENSMUSP00000106673
ENSMUST00000111043	ENSMUSP00000106672
ENSMUST00000111042	ENSMUSP00000106671
ENSMUST00000176893	ENSMUSP00000135762

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005169	neurotrophin TRKB receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001657	ureteric bud development
GO:0001662	behavioral fear response
GO:0001666	response to hypoxia
GO:0002544	chronic inflammatory response
GO:0006120	mitochondrial electron transport, NADH to ubiquinone
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007399	nervous system development
GO:0007406	negative regulation of neuroblast proliferation
GO:0007411	axon guidance
GO:0007412	axon target recognition
GO:0007611	learning or memory
GO:0007612	learning
GO:0007623	circadian rhythm
GO:0007631	feeding behavior
GO:0008038	neuron recognition
GO:0009416	response to light stimulus
GO:0009642	response to light intensity
GO:0009725	response to hormone
GO:0010996	response to auditory stimulus
GO:0014047	glutamate secretion
GO:0014076	response to fluoxetine
GO:0014823	response to activity
GO:0016358	dendrite development
GO:0019222	regulation of metabolic process
GO:0021675	nerve development
GO:0030516	regulation of axon extension
GO:0031667	response to nutrient levels
GO:0032094	response to food
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0033189	response to vitamin A
GO:0034612	response to tumor necrosis factor
GO:0035864	response to potassium ion
GO:0042490	mechanoreceptor differentiation
GO:0042493	response to drug
GO:0042596	fear response
GO:0043066	negative regulation of apoptotic process
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045666	positive regulation of neuron differentiation
GO:0045843	negative regulation of striated muscle tissue development
GO:0046668	regulation of retinal cell programmed cell death
GO:0048167	regulation of synaptic plasticity
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048170	positive regulation of long-term neuronal synaptic plasticity
GO:0048172	regulation of short-term neuronal synaptic plasticity
GO:0048675	axon extension
GO:0048839	inner ear development
GO:0050890	cognition
GO:0051602	response to electrical stimulus
GO:0051965	positive regulation of synapse assembly
GO:0055093	response to hyperoxia
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060548	negative regulation of cell death
GO:0061193	taste bud development
GO:0071356	cellular response to tumor necrosis factor
GO:0071874	cellular response to norepinephrine stimulus
GO:0072347	response to anesthetic
GO:0097484	dendrite extension
GO:1901215	negative regulation of neuron death
GO:1902065	response to L-glutamate
GO:1990089	response to nerve growth factor
GO:1990090	cellular response to nerve growth factor stimulus
GO:1990138	neuron projection extension

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0008021	synaptic vesicle
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030061	mitochondrial crista
GO:0030424	axon
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043204	perikaryon
GO:0048471	perinuclear region of cytoplasm