Version 5.4
Homo sapiens Gene: MAP3K12
Summary
InnateDB Gene IDBG-36895.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP3K12
Gene Name mitogen-activated protein kinase kinase kinase 12
Synonyms DLK; MEKK12; MUK; ZPK; ZPKP1
Species Homo sapiens
Ensembl Gene ENSG00000139625
Encoded Proteins
IDBP-36897
mitogen-activated protein kinase kinase kinase 12
IDBP-598974
mitogen-activated protein kinase kinase kinase 12
IDBP-598199
mitogen-activated protein kinase kinase kinase 12
IDBP-584059
mitogen-activated protein kinase kinase kinase 12
IDBP-717696
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20940047
MAP3K12 (DLK) and its downstream kinases contribute to the finely tuned regulation of CREB-dependent effects. MAP3K12 inhibits CREB activity by affecting the interaction of CREB with its second co-activator TORC.
Entrez Gene
Summary This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:53479669-53500063
Strand Reverse strand
Band q13.13
Transcripts
ENST00000267079 ENSP00000267079
ENST00000547020
ENST00000547488 ENSP00000449038
ENST00000551511
ENST00000547035 ENSP00000448689
ENST00000552365 ENSP00000447889
ENST00000548690
ENST00000547151
ENST00000551895
ENST00000547803
ENST00000548565 ENSP00000454355
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000186 activation of MAPKK activity
GO:0006468 protein phosphorylation
GO:0007254 JNK cascade
GO:0016572 histone phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0035556 intracellular signal transduction
GO:0045087 innate immune response (InnateDB)
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030424 axon
GO:0030426 growth cone
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023050
View Gene Order
ENSBTAG00000020758
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
p38alphabetapathway
Regulation of p38-alpha and p38-beta
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.713539
RefSeq NM_001193511 NM_006301 XM_005269138 XM_005269140 XM_006719588 XM_006719589
HUGO
OMIM
CCDS CCDS55831 CCDS8860
HPRD 02709
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca