Version 5.4
Mus musculus Gene: Map3k12
Summary
InnateDB Gene IDBG-188866.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Map3k12
Gene Name mitogen-activated protein kinase kinase kinase 12
Synonyms DLK; MUK; Zpk
Species Mus musculus
Ensembl Gene ENSMUSG00000023050
Encoded Proteins
IDBP-188868
mitogen-activated protein kinase kinase kinase 12
IDBP-626042
mitogen-activated protein kinase kinase kinase 12
IDBP-626046
mitogen-activated protein kinase kinase kinase 12
IDBP-626049
mitogen-activated protein kinase kinase kinase 12
IDBP-626050
mitogen-activated protein kinase kinase kinase 12
IDBP-626052
mitogen-activated protein kinase kinase kinase 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20940047
[Homo sapiens] MAP3K12 (DLK) and its downstream kinases contribute to the finely tuned regulation of CREB-dependent effects. MAP3K12 inhibits CREB activity by affecting the interaction of CREB with its second co-activator TORC.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139625:
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:102497649-102517064
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000023812 ENSMUSP00000023812
ENSMUST00000171565 ENSMUSP00000127629
ENSMUST00000169377 ENSMUSP00000133209
ENSMUST00000169367 ENSMUSP00000129472
ENSMUST00000165174 ENSMUSP00000130786
ENSMUST00000169162 ENSMUSP00000129251
ENSMUST00000164343
ENSMUST00000167677
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000186 activation of MAPKK activity
GO:0006468 protein phosphorylation
GO:0007254 JNK cascade
GO:0016572 histone phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030424 axon
GO:0030426 growth cone
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000139625
View Gene Order
ENSBTAG00000020758
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04010
MAPK signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
p38alphabetapathway
Regulation of p38-alpha and p38-beta
Cross-References
SwissProt Q60700
TrEMBL E9PUZ1 E9PZU4 E9QA89
UniProt Splice Variant
Entrez Gene 26404
UniGene Mm.172897 Mm.455622 Mm.485651
RefSeq NM_001163643 NM_009582 XM_006521012
OMIM
CCDS CCDS27885
HPRD
IMGT
MGI ID MGI:1346881
MGI Symbol Map3k12
EMBL AC137156 AK029882 AK034374 AK081623 AK166435 BC047158 BC057572 U14636 U23789
GenPept AAA57280 AAB17123 AAH47158 AAH57572 BAC26658 BAC28689 BAC38274 BAE38775
RNA Seq Atlas 26404

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca