Version 5.4
Homo sapiens Gene: SOX12
Summary
InnateDB Gene IDBG-36919.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOX12
Gene Name SRY (sex determining region Y)-box 12
Synonyms SOX22
Species Homo sapiens
Ensembl Gene ENSG00000177732
Encoded Proteins
IDBP-36923
SRY (sex determining region Y)-box 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:325401-330224
Strand Forward strand
Band p13
Transcripts
ENST00000342665 ENSP00000347646
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0003677 DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0021510 spinal cord development
GO:0045165 cell fate commitment
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0065004 protein-DNA complex assembly
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0032993 protein-DNA complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000051817
View Gene Order
Cross-References
SwissProt O15370
TrEMBL
UniProt Splice Variant
Entrez Gene 6666
UniGene Hs.43627 Hs.712815
RefSeq NM_006943
HUGO HGNC:11198
OMIM 601947
CCDS CCDS12995
HPRD
IMGT
EMBL AL034548 BC067361 U35612
GenPept AAB69627 AAH67361 CAB81632
RNA Seq Atlas 6666

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca