InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SOX12

Summary

InnateDB Protein

IDBP-36923.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOX12

Protein Name

SRY (sex determining region Y)-box 12

Synonyms

SOX22;

Species

Homo sapiens

Ensembl Protein

ENSP00000347646

InnateDB Gene

IDBG-36919 (SOX12)

Protein Structure

UniProt Annotation

Function

Binds to the sequence 5'-AACAAT-3'. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00267, ECO:0000269PubMed:9215677}.

Disease Associations

Tissue Specificity

Expressed most abundantly in the CNS. Also expressed in fetal brain and kidney and adult heart, pancreas, testis and ovary. Other tissues were only weakly positive. {ECO:0000269PubMed:9215677}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0003677	DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0021510	spinal cord development
GO:0045165	cell fate commitment
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0065004	protein-DNA complex assembly