InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NPFF

Summary

InnateDB Gene

IDBG-36991.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPFF

Gene Name

neuropeptide FF-amide peptide precursor

Synonyms

FMRFAL

Species

Homo sapiens

Ensembl Gene

ENSG00000139574

Encoded Proteins

IDBP-36995

neuropeptide FF-amide peptide precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

FMFRamide-related protein precursor plays a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. FMRFAL encodes a preproprotein which is cleaved to form two active peptides with similar function. [provided by RefSeq, Jul 2008]
FMFRamide-related protein precursor plays a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. FMRFAL encodes a preproprotein which is cleaved to form two active peptides with similar function. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:53506690-53507638

Strand

Reverse strand

Band

q13.13

Transcripts

ENST00000267017	ENSP00000267017
ENST00000448979

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005102	receptor binding
GO:0005184	neuropeptide hormone activity

Biological Process

GO:0002438	acute inflammatory response to antigenic stimulus
GO:0003254	regulation of membrane depolarization
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007268	synaptic transmission
GO:0010459	negative regulation of heart rate
GO:0021510	spinal cord development
GO:0030103	vasopressin secretion
GO:0032099	negative regulation of appetite
GO:0042493	response to drug
GO:0043278	response to morphine
GO:0045777	positive regulation of blood pressure
GO:0046676	negative regulation of insulin secretion
GO:0051930	regulation of sensory perception of pain
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060135	maternal process involved in female pregnancy
GO:0070253	somatostatin secretion