InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPFF

Summary

InnateDB Protein

IDBP-36995.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPFF

Protein Name

neuropeptide FF-amide peptide precursor

Synonyms

FMRFAL;

Species

Homo sapiens

Ensembl Protein

ENSP00000267017

InnateDB Gene

IDBG-36991 (NPFF)

Protein Structure

UniProt Annotation

Function

Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels. {ECO:0000269PubMed:11587714}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005102	receptor binding
GO:0005184	neuropeptide hormone activity

Biological Process

GO:0002438	acute inflammatory response to antigenic stimulus
GO:0003254	regulation of membrane depolarization
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007268	synaptic transmission
GO:0010459	negative regulation of heart rate
GO:0021510	spinal cord development
GO:0030103	vasopressin secretion
GO:0032099	negative regulation of appetite
GO:0042493	response to drug
GO:0043278	response to morphine
GO:0045777	positive regulation of blood pressure
GO:0046676	negative regulation of insulin secretion
GO:0051930	regulation of sensory perception of pain
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060135	maternal process involved in female pregnancy
GO:0070253	somatostatin secretion