Version 5.4
Homo sapiens Gene: FSHB
Summary
InnateDB Gene IDBG-37119.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FSHB
Gene Name follicle stimulating hormone, beta polypeptide
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000131808
Encoded Proteins
IDBP-37121
follicle stimulating hormone, beta polypeptide
IDBP-370101
follicle stimulating hormone, beta polypeptide
IDBP-584492
follicle stimulating hormone, beta polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:30231016-30235261
Strand Forward strand
Band p14.1
Transcripts
ENST00000254122 ENSP00000254122
ENST00000417547 ENSP00000416606
ENST00000533718 ENSP00000433424
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005515 protein binding
Biological Process
GO:0001541 ovarian follicle development
GO:0006701 progesterone biosynthetic process
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007292 female gamete generation
GO:0007565 female pregnancy
GO:0008284 positive regulation of cell proliferation
GO:0016486 peptide hormone processing
GO:0030335 positive regulation of cell migration
GO:0042699 follicle-stimulating hormone signaling pathway
GO:0044267 cellular protein metabolic process
GO:0045670 regulation of osteoclast differentiation
GO:0045780 positive regulation of bone resorption
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060011 Sertoli cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027120
View Gene Order
ENSBTAG00000010889
Not yet available
Pathways
NETPATH
NetPath_25
FSH pathway
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_16942
Hormone ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_15398
Glycoprotein hormones pathway
REACT_15452
Peptide hormone biosynthesis pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_17015
Metabolism of proteins pathway
REACT_21340
GPCR ligand binding pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.36975
RefSeq NM_000510 NM_001018080
HUGO
OMIM
CCDS CCDS7868
HPRD 00644
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca