Version 5.4
Homo sapiens Protein: FSHB
Summary
InnateDB Protein IDBP-37121.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FSHB
Protein Name follicle stimulating hormone, beta polypeptide
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000254122
InnateDB Gene IDBG-37119 (FSHB)
Protein Structure
UniProt Annotation
Function Stimulates development of follicle and spermatogenesis in the reproductive organs.
Subcellular Localization Secreted.
Disease Associations Isolated follicle-stimulating hormone deficiency (IFSHD) [MIM:229070]: Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men. {ECO:0000269PubMed:8220432, ECO:0000269PubMed:9271483, ECO:0000269PubMed:9280841}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005515 protein binding
Biological Process
GO:0006701 progesterone biosynthetic process
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007292 female gamete generation
GO:0007565 female pregnancy
GO:0008284 positive regulation of cell proliferation
GO:0016486 peptide hormone processing
GO:0030335 positive regulation of cell migration
GO:0044267 cellular protein metabolic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001545 Gonadotropin, beta subunit
IPR006208 Glycoprotein hormone subunit beta, cystine knot
IPR029034 Cystine-knot cytokine
PFAM PF00007
PRINTS
PIRSF
SMART SM00068
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P01225
PhosphoSite PhosphoSite-P01225
TrEMBL Q27RP3
UniProt Splice Variant
Entrez Gene 2488
UniGene Hs.36975
RefSeq NP_000501
HUGO HGNC:3964
OMIM 136530
CCDS CCDS7868
HPRD 00644
IMGT
EMBL AL358944 BC113488 BC113490 CH471064 DQ386645 DQ434892 EF198021 EF585489 EF585490 EU081884 EU081885 M16646 M16647 M24539 M24540 M54913 M54914
GenPept AAA52470 AAA52476 AAB02868 AAI13489 AAI13491 ABD46886 ABD84005 ABM88373 ABQ57401 ABQ57402 ABU96749 ABU96750 EAW68260

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca