Version 5.4
Homo sapiens Gene: PTK2
Summary
InnateDB Gene IDBG-37147.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTK2
Gene Name PTK2 protein tyrosine kinase 2
Synonyms FADK; FAK; FAK1; FRNK; p125FAK; pp125FAK; PPP1R71
Species Homo sapiens
Ensembl Gene ENSG00000169398
Encoded Proteins
IDBP-37151
PTK2 protein tyrosine kinase 2
IDBP-239957
PTK2 protein tyrosine kinase 2
IDBP-377047
PTK2 protein tyrosine kinase 2
IDBP-480322
PTK2 protein tyrosine kinase 2
IDBP-476748
PTK2 protein tyrosine kinase 2
IDBP-483087
PTK2 protein tyrosine kinase 2
IDBP-482350
PTK2 protein tyrosine kinase 2
IDBP-475637
PTK2 protein tyrosine kinase 2
IDBP-482576
PTK2 protein tyrosine kinase 2
IDBP-482906
PTK2 protein tyrosine kinase 2
IDBP-474577
PTK2 protein tyrosine kinase 2
IDBP-484119
PTK2 protein tyrosine kinase 2
IDBP-483655
PTK2 protein tyrosine kinase 2
IDBP-474829
PTK2 protein tyrosine kinase 2
IDBP-481031
PTK2 protein tyrosine kinase 2
IDBP-474140
PTK2 protein tyrosine kinase 2
IDBP-474447
PTK2 protein tyrosine kinase 2
IDBP-484818
PTK2 protein tyrosine kinase 2
IDBP-477933
PTK2 protein tyrosine kinase 2
IDBP-480280
PTK2 protein tyrosine kinase 2
IDBP-474049
PTK2 protein tyrosine kinase 2
IDBP-483918
PTK2 protein tyrosine kinase 2
IDBP-476112
PTK2 protein tyrosine kinase 2
IDBP-482552
PTK2 protein tyrosine kinase 2
IDBP-478713
PTK2 protein tyrosine kinase 2
IDBP-480343
PTK2 protein tyrosine kinase 2
IDBP-481896
PTK2 protein tyrosine kinase 2
IDBP-483447
PTK2 protein tyrosine kinase 2
IDBP-482685
PTK2 protein tyrosine kinase 2
IDBP-476232
PTK2 protein tyrosine kinase 2
IDBP-477444
PTK2 protein tyrosine kinase 2
IDBP-479741
PTK2 protein tyrosine kinase 2
IDBP-478980
PTK2 protein tyrosine kinase 2
IDBP-475441
PTK2 protein tyrosine kinase 2
IDBP-482887
PTK2 protein tyrosine kinase 2
IDBP-475507
PTK2 protein tyrosine kinase 2
IDBP-475244
PTK2 protein tyrosine kinase 2
IDBP-483767
PTK2 protein tyrosine kinase 2
IDBP-475100
PTK2 protein tyrosine kinase 2
IDBP-482667
PTK2 protein tyrosine kinase 2
IDBP-476805
PTK2 protein tyrosine kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18353772
PTK2 induces KLF8 expression in human ovarian cancer cells by activating the PI3K-Akt signalling pathway.
Entrez Gene
Summary This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:140657900-141002216
Strand Reverse strand
Band q24.3
Transcripts
ENST00000340930 ENSP00000341189
ENST00000395218 ENSP00000378644
ENST00000430260 ENSP00000403416
ENST00000522684 ENSP00000429911
ENST00000519654 ENSP00000429929
ENST00000519465 ENSP00000429170
ENST00000517887 ENSP00000429082
ENST00000521059 ENSP00000429474
ENST00000517712 ENSP00000430916
ENST00000523539 ENSP00000428492
ENST00000519993 ENSP00000428570
ENST00000519419 ENSP00000429129
ENST00000524202 ENSP00000429023
ENST00000521986 ENSP00000430603
ENST00000523435 ENSP00000430828
ENST00000522950 ENSP00000429437
ENST00000523805
ENST00000520460
ENST00000521985
ENST00000518173
ENST00000522424 ENSP00000427774
ENST00000521562 ENSP00000431106
ENST00000521250 ENSP00000427972
ENST00000523388 ENSP00000429702
ENST00000521981 ENSP00000428593
ENST00000521029 ENSP00000429958
ENST00000518509
ENST00000520917
ENST00000520151 ENSP00000428482
ENST00000523670 ENSP00000428380
ENST00000519024 ENSP00000428232
ENST00000523746
ENST00000510126
ENST00000523474
ENST00000519899
ENST00000519361
ENST00000520843
ENST00000521172
ENST00000524357 ENSP00000429001
ENST00000521791 ENSP00000427825
ENST00000523067 ENSP00000429895
ENST00000520828 ENSP00000427762
ENST00000520475 ENSP00000428792
ENST00000519881 ENSP00000430277
ENST00000520892 ENSP00000427904
ENST00000523803 ENSP00000429530
ENST00000521907 ENSP00000427795
ENST00000517453 ENSP00000430951
ENST00000520045 ENSP00000430044
ENST00000521395 ENSP00000429907
ENST00000523675
ENST00000521332 ENSP00000429409
ENST00000524040 ENSP00000430037
ENST00000523679 ENSP00000429028
ENST00000524257 ENSP00000431023
ENST00000523797
ENST00000519635
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 166 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 166 [view]
Protein-Protein 165 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008432 JUN kinase binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0042169 SH2 domain binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001570 vasculogenesis
GO:0001764 neuron migration
GO:0001890 placenta development
GO:0001934 positive regulation of protein phosphorylation
GO:0003007 heart morphogenesis
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0007165 signal transduction
GO:0007172 signal complex assembly
GO:0007229 integrin-mediated signaling pathway
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0008360 regulation of cell shape
GO:0009790 embryo development
GO:0010594 regulation of endothelial cell migration
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021955 central nervous system neuron axonogenesis
GO:0022408 negative regulation of cell-cell adhesion
GO:0030010 establishment of cell polarity
GO:0030168 platelet activation
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0032319 regulation of Rho GTPase activity
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0038007 netrin-activated signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0040023 establishment of nucleus localization
GO:0042127 regulation of cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0043542 endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 innate immune response (InnateDB)
GO:0045667 regulation of osteoblast differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0046621 negative regulation of organ growth
GO:0046777 protein autophosphorylation
GO:0048013 ephrin receptor signaling pathway
GO:0048870 cell motility
GO:0050771 negative regulation of axonogenesis
GO:0051493 regulation of cytoskeleton organization
GO:0051893 regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0051964 negative regulation of synapse assembly
GO:0060396 growth hormone receptor signaling pathway
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000811 negative regulation of anoikis
Cellular Component
GO:0005634 nucleus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0016324 apical plasma membrane
GO:0030027 lamellipodium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022607
View Gene Order
ENSBTAG00000009578
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_2
AndrogenReceptor pathway
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_18
IL6 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_23
TSH pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_15443
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
REACT_15381
p130Cas linkage to MAPK signaling for integrins pathway
REACT_15523
Integrin alphaIIb beta3 signaling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_23916
Signal regulatory protein (SIRP) family interactions pathway
REACT_22384
Netrin mediated repulsion signals pathway
REACT_22351
DCC mediated attractive signaling pathway
REACT_22237
Netrin-1 signaling pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_111155
Cell-Cell communication pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_12529
Signaling by VEGF pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_18266
Axon guidance pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_6900
Immune System pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04370
VEGF signaling pathway pathway
hsa04012
ErbB signaling pathway pathway
hsa04360
Axon guidance pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa05222
Small cell lung cancer pathway
hsa04510
Focal adhesion pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa05146
Amoebiasis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
Integrin signaling pathway pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
ar_nongenomic_pathway
Nongenotropic Androgen signaling
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
caspase_pathway
Caspase Cascade in Apoptosis
lysophospholipid_pathway
LPA receptor mediated events
cxcr4_pathway
CXCR4-mediated signaling events
netrin_pathway
Netrin-mediated signaling events
avb3_integrin_pathway
Integrins in angiogenesis
erbb1_internalization_pathway
Internalization of ErbB1
nectin_pathway
Nectin adhesion pathway
fak_pathway
Signaling events mediated by focal adhesion kinase
igf1_pathway
IGF1 pathway
ephbfwdpathway
EPHB forward signaling
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
syndecan_4_pathway
Syndecan-4-mediated signaling events
ret_pathway
Signaling events regulated by Ret tyrosine kinase
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
epha2_fwdpathway
EPHA2 forward signaling
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
a4b7_pathway
a4b7 Integrin signaling
Cross-References
SwissProt
TrEMBL E5RI03
UniProt Splice Variant
Entrez Gene 5747
UniGene Hs.395482 Hs.712239 Hs.735374 Hs.736231
RefSeq NM_001199649 NM_005607 NM_153831 XM_005251006 XM_005251007 XM_005251008 XM_005251010 XM_005251011 XM_005251014 XM_006716607
HUGO HGNC:9611
OMIM 600758
CCDS CCDS56557 CCDS6381
HPRD 02859
IMGT
EMBL AC067931 AC100860 AC105009 AC105235
GenPept
RNA Seq Atlas 5747

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca