Version 5.4
Bos taurus Gene: PTK2
Summary
InnateDB Gene IDBG-643924.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTK2
Gene Name PTK2 protein tyrosine kinase 2
Synonyms FADK
Species Bos taurus
Ensembl Gene ENSBTAG00000009578
Encoded Proteins
IDBP-696579
PTK2 protein tyrosine kinase 2Uncharacterized protein
IDBP-696585
PTK2 protein tyrosine kinase 2Uncharacterized protein
IDBP-696588
PTK2 protein tyrosine kinase 2Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18353772
[Homo sapiens] PTK2 induces KLF8 expression in human ovarian cancer cells by activating the PI3K-Akt signalling pathway.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169398:
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:3870893-4065010
Strand Forward strand
Band
Transcripts
ENSBTAT00000064860 ENSBTAP00000056419
ENSBTAT00000012605 ENSBTAP00000012605
ENSBTAT00000012601 ENSBTAP00000012601
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 118 interaction(s) predicted by orthology.
Predicted by orthology
Total 118 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003779 actin binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008432 JUN kinase binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0042169 SH2 domain binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001570 vasculogenesis
GO:0001764 neuron migration
GO:0001934 positive regulation of protein phosphorylation
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007172 signal complex assembly
GO:0007229 integrin-mediated signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0008360 regulation of cell shape
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021955 central nervous system neuron axonogenesis
GO:0022408 negative regulation of cell-cell adhesion
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0040023 establishment of nucleus localization
GO:0042127 regulation of cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0043542 endothelial cell migration
GO:0045667 regulation of osteoblast differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0046621 negative regulation of organ growth
GO:0046777 protein autophosphorylation
GO:0048013 ephrin receptor signaling pathway
GO:0050771 negative regulation of axonogenesis
GO:0051897 positive regulation of protein kinase B signaling
GO:0051964 negative regulation of synapse assembly
GO:0060396 growth hormone receptor signaling pathway
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000811 negative regulation of anoikis
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0016324 apical plasma membrane
GO:0030027 lamellipodium
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000169398
View Gene Order
ENSMUSG00000022607
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_2
AndrogenReceptor pathway
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_18
IL6 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_23
TSH pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_15443
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
REACT_15381
p130Cas linkage to MAPK signaling for integrins pathway
REACT_15523
Integrin alphaIIb beta3 signaling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_23916
Signal regulatory protein (SIRP) family interactions pathway
REACT_22384
Netrin mediated repulsion signals pathway
REACT_22351
DCC mediated attractive signaling pathway
REACT_22237
Netrin-1 signaling pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_111155
Cell-Cell communication pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_12529
Signaling by VEGF pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_18266
Axon guidance pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_6900
Immune System pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_604
Hemostasis pathway
REACT_239142
Innate Immune System pathway
REACT_198374
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_258521
Apoptosis pathway
REACT_224553
Hemostasis pathway
REACT_229826
Netrin-1 signaling pathway
REACT_227951
Signaling by VEGF pathway
REACT_243939
EPHA-mediated growth cone collapse pathway
REACT_224460
Apoptotic cleavage of cellular proteins pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_248291
DCC mediated attractive signaling pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_257656
EPHB-mediated forward signaling pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_261444
Axon guidance pathway
REACT_238268
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_188576
Developmental Biology pathway
REACT_240371
p130Cas linkage to MAPK signaling for integrins pathway
REACT_188257
Signal Transduction pathway
REACT_246176
Integrin alphaIIb beta3 signaling pathway
REACT_249309
Platelet Aggregation (Plug Formation) pathway
REACT_237796
NCAM signaling for neurite out-growth pathway
REACT_207035
Apoptotic execution phase pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04370
VEGF signaling pathway pathway
hsa04012
ErbB signaling pathway pathway
hsa04360
Axon guidance pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa05222
Small cell lung cancer pathway
hsa04510
Focal adhesion pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa05146
Amoebiasis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
mmu04360
Axon guidance pathway
mmu04012
ErbB signaling pathway pathway
mmu04370
VEGF signaling pathway pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu05222
Small cell lung cancer pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu04510
Focal adhesion pathway
mmu04062
Chemokine signaling pathway pathway
mmu05200
Pathways in cancer pathway
mmu05146
Amoebiasis pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
Integrin signaling pathway pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
Integrin signaling pathway pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
ar_nongenomic_pathway
Nongenotropic Androgen signaling
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
caspase_pathway
Caspase Cascade in Apoptosis
lysophospholipid_pathway
LPA receptor mediated events
cxcr4_pathway
CXCR4-mediated signaling events
netrin_pathway
Netrin-mediated signaling events
avb3_integrin_pathway
Integrins in angiogenesis
erbb1_internalization_pathway
Internalization of ErbB1
nectin_pathway
Nectin adhesion pathway
fak_pathway
Signaling events mediated by focal adhesion kinase
igf1_pathway
IGF1 pathway
ephbfwdpathway
EPHB forward signaling
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
syndecan_4_pathway
Syndecan-4-mediated signaling events
ret_pathway
Signaling events regulated by Ret tyrosine kinase
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
epha2_fwdpathway
EPHA2 forward signaling
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
a4b7_pathway
a4b7 Integrin signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.63222
RefSeq NM_001075250
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca