InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PARD6A

Summary

InnateDB Gene

IDBG-37154.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PARD6A

Gene Name

par-6 partitioning defective 6 homolog alpha (C. elegans)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000102981

Encoded Proteins

IDBP-37156

par-6 partitioning defective 6 homolog alpha (C. elegans)

IDBP-379297

par-6 partitioning defective 6 homolog alpha (C. elegans)

IDBP-813301

par-6 family cell polarity regulator alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:67660946-67662778

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000219255	ENSP00000219255
ENST00000458121	ENSP00000392388
ENST00000602551	ENSP00000473257
ENST00000602727

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	50 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0017048	Rho GTPase binding
GO:0030742	GTP-dependent protein binding

Biological Process

GO:0007049	cell cycle
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0016032	viral process
GO:0034329	cell junction assembly
GO:0045216	cell-cell junction organization
GO:0045217	cell-cell junction maintenance
GO:0051301	cell division
GO:0070830	tight junction assembly

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0005938	cell cortex
GO:0043234	protein complex
GO:0045177	apical part of cell