Version 5.4
Mus musculus Gene: Pard6a
Summary
InnateDB Gene IDBG-188416.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pard6a
Gene Name par-6 (partitioning defective 6,) homolog alpha (C. elegans)
Synonyms 0710008C04Rik; 2610010A15Rik; Par-6; PAR-6A; Par6; PAR6alpha; Par6c; TAX40; Tip-40
Species Mus musculus
Ensembl Gene ENSMUSG00000005699
Encoded Proteins
IDBP-188418
par-6 (partitioning defective 6,) homolog alpha (C. elegans)
IDBP-188420
par-6 (partitioning defective 6,) homolog alpha (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102981:
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:105701154-105703493
Strand Forward strand
Band D3
Transcripts
ENSMUST00000093195 ENSMUSP00000090886
ENSMUST00000098444 ENSMUSP00000096043
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0017048 Rho GTPase binding
GO:0030742 GTP-dependent protein binding
Biological Process
GO:0007049 cell cycle
GO:0030010 establishment of cell polarity
GO:0045217 cell-cell junction maintenance
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0005938 cell cortex
GO:0030054 cell junction
GO:0043234 protein complex
GO:0045177 apical part of cell
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102981
View Gene Order
ENSBTAG00000023734
Not yet available
Pathways
NETPATH
REACTOME
REACT_217958
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_215068
Loss of Function of SMAD4 in Cancer pathway
REACT_226355
beta-catenin independent WNT signaling pathway
REACT_213336
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_224217
TGFBR1 LBD Mutants in Cancer pathway
REACT_248094
Cell-cell junction organization pathway
REACT_204241
Loss of Function of TGFBR2 in Cancer pathway
REACT_214043
PCP/CE pathway pathway
REACT_196549
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
REACT_216792
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_224787
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_223317
Loss of Function of TGFBR1 in Cancer pathway
REACT_209370
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_203973
Asymmetric localization of PCP proteins pathway
REACT_202264
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_188257
Signal Transduction pathway
REACT_224802
TGFBR1 KD Mutants in Cancer pathway
REACT_241978
Cell junction organization pathway
REACT_236746
Tight junction interactions pathway
REACT_223082
Cell-Cell communication pathway
REACT_225428
Signaling by TGF-beta Receptor Complex pathway
REACT_226256
Loss of Function of SMAD2/3 in Cancer pathway
KEGG
mmu04530
Tight junction pathway
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_120726
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
REACT_19373
Tight junction interactions pathway
REACT_172581
PCP/CE pathway pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_111155
Cell-Cell communication pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_20676
Cell junction organization pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_172638
Asymmetric localization of PCP proteins pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_19331
Cell-cell junction organization pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
hsa04530
Tight junction pathway
hsa04144
Endocytosis pathway
INOH
PID NCI
nephrin_neph1_pathway
Nephrin/Neph1 signaling in the kidney podocyte
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
cdc42_pathway
CDC42 signaling events
tgfbrpathway
TGF-beta receptor signaling
rhoa_pathway
RhoA signaling pathway
insulin_pathway
Insulin Pathway
Cross-References
SwissProt Q9Z101
TrEMBL Q3TY70
UniProt Splice Variant
Entrez Gene 56513
UniGene Mm.472753
RefSeq NM_001047435 NM_019695 NM_001047436 XM_006531211 XM_006531212
OMIM
CCDS CCDS22609 CCDS40462
HPRD
IMGT
MGI ID MGI:1927223
MGI Symbol Pard6a
EMBL AF070970 AK158848 BC049593 BC061114
GenPept AAD15928 AAH49593 AAH61114 BAE34693
RNA Seq Atlas 56513

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca