Version 5.4
Homo sapiens Gene: HOXC10
Summary
InnateDB Gene IDBG-37317.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOXC10
Gene Name homeobox C10
Synonyms HOX3I
Species Homo sapiens
Ensembl Gene ENSG00000180818
Encoded Proteins
IDBP-37319
homeobox C10
IDBP-476036
homeobox C10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:53985065-53990279
Strand Forward strand
Band q13.13
Transcripts
ENST00000303460 ENSP00000307321
ENST00000515593 ENSP00000421946
ENST00000511575
ENST00000514415
ENST00000513413
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001501 skeletal system development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008284 positive regulation of cell proliferation
GO:0009952 anterior/posterior pattern specification
GO:0009954 proximal/distal pattern formation
GO:0021520 spinal cord motor neuron cell fate specification
GO:0030326 embryonic limb morphogenesis
GO:0050905 neuromuscular process
Cellular Component
GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022484
View Gene Order
ENSBTAG00000003278
Not yet available
Cross-References
SwissProt
TrEMBL D6RAG4
UniProt Splice Variant
Entrez Gene 3226
UniGene Hs.44276 Hs.605917 Hs.691127
RefSeq NM_017409
HUGO HGNC:5122
OMIM 605560
CCDS CCDS8868
HPRD 05710
IMGT
EMBL AC012531
GenPept
RNA Seq Atlas 3226

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca