Version 5.4
Homo sapiens Gene: ELP4
Summary
InnateDB Gene IDBG-37364.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELP4
Gene Name elongator acetyltransferase complex subunit 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000109911
Encoded Proteins
IDBP-37366
elongation protein 4 homolog (S. cerevisiae)
IDBP-37368
elongation protein 4 homolog (S. cerevisiae)
IDBP-238539
elongation protein 4 homolog (S. cerevisiae)
IDBP-588563
elongation protein 4 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:31509750-31783998
Strand Forward strand
Band p13
Transcripts
ENST00000350638 ENSP00000298937
ENST00000379163 ENSP00000368461
ENST00000395934 ENSP00000379267
ENST00000474374 ENSP00000432642
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 16 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008607 phosphorylase kinase regulator activity
Biological Process
GO:0006325 chromatin organization
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0016573 histone acetylation
GO:0045859 regulation of protein kinase activity
Cellular Component
GO:0005737 cytoplasm
GO:0008023 transcription elongation factor complex
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
GO:0033588 Elongator holoenzyme complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027167
View Gene Order
ENSBTAG00000023831
Not yet available
Pathways
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q96EB1
TrEMBL E9PPJ9 G5E9D4 Q9H4R8
UniProt Splice Variant
Entrez Gene 26610
UniGene Hs.175534
RefSeq NM_001288725 NM_001288726 NM_019040 XM_005252865
HUGO HGNC:1171
OMIM 606985
CCDS CCDS73271 CCDS73272 CCDS7875
HPRD
IMGT
EMBL AC108456 AC131571 AJ276005 AK000505 AK304885 AL136677 AL390767 BC012514 CH471064 Z83001 Z83306 Z83307
GenPept AAH12514 BAA91212 BAG65622 CAB66612 CAC08200 CAC10331 CAM13056 EAW68238
RNA Seq Atlas 26610

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca