InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HOXC6

Summary

InnateDB Gene

IDBG-37416.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOXC6

Gene Name

homeobox C6

Synonyms

CP25; HHO.C8; HOX3; HOX3C

Species

Homo sapiens

Ensembl Gene

ENSG00000197757

Encoded Proteins

IDBP-37418

homeobox C6

IDBP-241812

homeobox C6

IDBP-482424

homeobox C6

IDBP-481114

homeobox C6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [provided by RefSeq, Jul 2008]
This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5\' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:53990624-54030823

Strand

Forward strand

Band

q13.13

Transcripts

ENST00000243108	ENSP00000243108
ENST00000394331	ENSP00000377864
ENST00000504315	ENSP00000424124
ENST00000509328	ENSP00000423898

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007275	multicellular organismal development
GO:0009952	anterior/posterior pattern specification
GO:0048706	embryonic skeletal system development

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000001661

View Gene Order

ENSBTAG00000009238

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.735752

RefSeq

NM_004503 NM_153693

HUGO

OMIM

CCDS

CCDS41792 CCDS8871

HPRD

00858

IMGT

EMBL

GenPept

RNA Seq Atlas