Version 5.4
Homo sapiens Gene: CAPZA2
Summary
InnateDB Gene IDBG-37476.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAPZA2
Gene Name capping protein (actin filament) muscle Z-line, alpha 2
Synonyms CAPPA2; CAPZ
Species Homo sapiens
Ensembl Gene ENSG00000198898
Encoded Proteins
IDBP-37478
capping protein (actin filament) muscle Z-line, alpha 2
IDBP-385631
capping protein (actin filament) muscle Z-line, alpha 2
IDBP-385633
capping protein (actin filament) muscle Z-line, alpha 2
IDBP-476033
capping protein (actin filament) muscle Z-line, alpha 2
IDBP-484194
capping protein (actin filament) muscle Z-line, alpha 2
IDBP-485481
capping protein (actin filament) muscle Z-line, alpha 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:116811070-116922049
Strand Forward strand
Band q31.2
Transcripts
ENST00000361183 ENSP00000354947
ENST00000414148
ENST00000449080 ENSP00000408150
ENST00000426421 ENSP00000395395
ENST00000417431
ENST00000464223 ENSP00000420640
ENST00000484325 ENSP00000418262
ENST00000490693 ENSP00000419484
ENST00000461878
ENST00000466023
ENST00000464669
ENST00000465607
ENST00000496161
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 21 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0006461 protein complex assembly
GO:0006928 cellular component movement
GO:0007596 blood coagulation
GO:0030036 actin cytoskeleton organization
GO:0045087 innate immune response
GO:0051016 barbed-end actin filament capping
GO:0051693 actin filament capping
Cellular Component
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0008290 F-actin capping protein complex
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0030863 cortical cytoskeleton
GO:0070062 extracellular vesicular exosome
GO:0071203 WASH complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015733
View Gene Order
ENSBTAG00000004072
Not yet available
Pathways
NETPATH
REACTOME
REACT_25195
Advanced glycosylation endproduct receptor signaling pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.446123
RefSeq NM_006136
HUGO
OMIM
CCDS CCDS5768
HPRD 11871
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca