InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HOXC4

Summary

InnateDB Gene

IDBG-37502.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOXC4

Gene Name

homeobox C4

Synonyms

cp19; HOX3; HOX3E

Species

Homo sapiens

Ensembl Gene

ENSG00000198353

Encoded Proteins

IDBP-37504

homeobox C4

IDBP-376646

homeobox C4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons. [provided by RefSeq, Jul 2008]
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5\' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:54016931-54056030

Strand

Forward strand

Band

q13.13

Transcripts

ENST00000303406	ENSP00000305973
ENST00000430889	ENSP00000399808
ENST00000507650

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0071837	HMG box domain binding

Biological Process

GO:0001501	skeletal system development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0009952	anterior/posterior pattern specification
GO:0048562	embryonic organ morphogenesis
GO:0051216	cartilage development

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000075394

View Gene Order

ENSBTAG00000003304

Not yet available

Cross-References

SwissProt

P09017

TrEMBL

A0A024RB51

UniProt Splice Variant

Entrez Gene

3221

UniGene

Hs.549040 Hs.690229

RefSeq

NM_014620 NM_153633

HUGO

HGNC:5126

OMIM

142974

CCDS

CCDS8873

HPRD

00860

IMGT

EMBL

AC023794 AY014297 AY014298 CH471054 X07495

GenPept

AAG42145 CAA30376 EAW96744 EAW96749

RNA Seq Atlas

3221