InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PLK4

Summary

InnateDB Gene

IDBG-37545.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLK4

Gene Name

polo-like kinase 4

Synonyms

SAK; STK18

Species

Homo sapiens

Ensembl Gene

ENSG00000142731

Encoded Proteins

IDBP-37547

polo-like kinase 4

IDBP-480736

polo-like kinase 4

IDBP-485274

polo-like kinase 4

IDBP-478795

polo-like kinase 4

IDBP-480442

polo-like kinase 4

IDBP-478759

polo-like kinase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:127880861-127899195

Strand

Forward strand

Band

q28.1

Transcripts

ENST00000270861	ENSP00000270861
ENST00000511942
ENST00000503914
ENST00000515069	ENSP00000421774
ENST00000513090	ENSP00000427554
ENST00000507249	ENSP00000423412
ENST00000514379	ENSP00000423582
ENST00000510605
ENST00000507454
ENST00000508113	ENSP00000427568
ENST00000510192

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	19 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	5 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0007099	centriole replication
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0046601	positive regulation of centriole replication
GO:0060707	trophoblast giant cell differentiation
GO:0098535	de novo centriole assembly