InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PLK4

Summary

InnateDB Gene

IDBG-630057.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLK4

Gene Name

Serine/threonine-protein kinase PLK4

Synonyms

PLK-4

Species

Bos taurus

Ensembl Gene

ENSBTAG00000039552

Encoded Proteins

IDBP-681503

Serine/threonine-protein kinase PLK4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142731:
This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:30185756-30202777

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000055868

ENSBTAP00000048808

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007099	centriole replication
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0046601	positive regulation of centriole replication
GO:0060707	trophoblast giant cell differentiation
GO:0098535	de novo centriole assembly