InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WNT2

Summary

InnateDB Gene

IDBG-37593.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT2

Gene Name

wingless-type MMTV integration site family member 2

Synonyms

INT1L1; IRP

Species

Homo sapiens

Ensembl Gene

ENSG00000105989

Encoded Proteins

IDBP-37595

wingless-type MMTV integration site family member 2

IDBP-385725

wingless-type MMTV integration site family member 2

IDBP-473904

wingless-type MMTV integration site family member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:117276631-117323289

Strand

Reverse strand

Band

q31.2

Transcripts

ENST00000265441	ENSP00000265441
ENST00000449446	ENSP00000389643
ENST00000491214	ENSP00000419466
ENST00000461427

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0048018	receptor agonist activity

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002088	lens development in camera-type eye
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0008284	positive regulation of cell proliferation
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0030324	lung development
GO:0045165	cell fate commitment
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048146	positive regulation of fibroblast proliferation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0055009	atrial cardiac muscle tissue morphogenesis
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060070	canonical Wnt signaling pathway
GO:0060317	cardiac epithelial to mesenchymal transition
GO:0060492	lung induction
GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060716	labyrinthine layer blood vessel development
GO:0061072	iris morphogenesis
GO:0061180	mammary gland epithelium development
GO:0071300	cellular response to retinoic acid
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0031012	extracellular matrix