InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Wnt2

Summary

InnateDB Gene

IDBG-129144.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wnt2

Gene Name

wingless-related MMTV integration site 2

Synonyms

2610510E18Rik; Int1l1; Irp; Mirp; Wnt-2; Wnt2a

Species

Mus musculus

Ensembl Gene

ENSMUSG00000010797

Encoded Proteins

IDBP-129146

wingless-related MMTV integration site 2

IDBP-537898

wingless-related MMTV integration site 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105989:
This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:17988940-18030585

Strand

Reverse strand

Band

Transcripts

ENSMUST00000010941	ENSMUSP00000010941
ENSMUST00000156317	ENSMUSP00000120589

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005125	cytokine activity
GO:0005515	protein binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0008284	positive regulation of cell proliferation
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0030324	lung development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048146	positive regulation of fibroblast proliferation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0055009	atrial cardiac muscle tissue morphogenesis
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060070	canonical Wnt signaling pathway
GO:0060317	cardiac epithelial to mesenchymal transition
GO:0060492	lung induction
GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060716	labyrinthine layer blood vessel development
GO:0061180	mammary gland epithelium development
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0031012	extracellular matrix