Version 5.4
Homo sapiens Gene: PSCA
Summary
InnateDB Gene IDBG-37716.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSCA
Gene Name prostate stem cell antigen
Synonyms PRO232
Species Homo sapiens
Ensembl Gene ENSG00000167653
Encoded Proteins
IDBP-37718
prostate stem cell antigen
IDBP-477955
prostate stem cell antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:142670308-142682724
Strand Forward strand
Band q24.3
Transcripts
ENST00000301258 ENSP00000301258
ENST00000505305
ENST00000510969
ENST00000513264 ENSP00000426508
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000022598
View Gene Order
Cross-References
SwissProt
TrEMBL H0YAA6
UniProt Splice Variant
Entrez Gene 8000
UniGene
RefSeq NM_005672
HUGO HGNC:9500
OMIM 602470
CCDS CCDS47925
HPRD 03919
IMGT
EMBL AC108002
GenPept
RNA Seq Atlas 8000

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca