Version 5.4
Homo sapiens Protein: PSCA
Summary
InnateDB Protein IDBP-37718.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSCA
Protein Name prostate stem cell antigen
Synonyms PRO232;
Species Homo sapiens
Ensembl Protein ENSP00000301258
InnateDB Gene IDBG-37716 (PSCA)
Protein Structure
UniProt Annotation
Function May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. {ECO:0000269PubMed:18488030}.
Subcellular Localization Cell membrane; Lipid-anchor, GPI-anchor.
Disease Associations
Tissue Specificity Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen- independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level). {ECO:0000269PubMed:10713670, ECO:0000269PubMed:18488030}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001526 CD59 antigen
IPR016054 Ly-6 antigen / uPA receptor -like
PFAM PF00021
PRINTS
PIRSF
SMART SM00134
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43653
PhosphoSite PhosphoSite-O43653
TrEMBL D3DWI6
UniProt Splice Variant
Entrez Gene 8000
UniGene
RefSeq NP_005663
HUGO HGNC:9500
OMIM 602470
CCDS CCDS47925
HPRD 03919
IMGT
EMBL AC108002 AF043498 AJ297436 AY358912 BC023582 BC065183 CH471162
GenPept AAC39607 AAH23582 AAH65183 AAQ89271 CAB97347 EAW82312 EAW82313

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca