InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NFE2

Summary

InnateDB Gene

IDBG-37778.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFE2

Gene Name

nuclear factor (erythroid-derived 2), 45kDa

Synonyms

NF-E2; p45

Species

Homo sapiens

Ensembl Gene

ENSG00000123405

Encoded Proteins

IDBP-37780

nuclear factor (erythroid-derived 2), 45kDa

IDBP-376831

nuclear factor (erythroid-derived 2), 45kDa

IDBP-599171

nuclear factor (erythroid-derived 2), 45kDa

IDBP-592053

nuclear factor (erythroid-derived 2), 45kDa

IDBP-585379

nuclear factor (erythroid-derived 2), 45kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:54292111-54301121

Strand

Reverse strand

Band

q13.13

Transcripts

ENST00000312156	ENSP00000312436
ENST00000435572	ENSP00000397185
ENST00000540264	ENSP00000439120
ENST00000553070	ENSP00000447558
ENST00000553198	ENSP00000446929

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0047485	protein N-terminus binding
GO:0050699	WW domain binding

Biological Process

GO:0006337	nucleosome disassembly
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0007596	blood coagulation
GO:0007599	hemostasis
GO:0008015	blood circulation
GO:0030502	negative regulation of bone mineralization
GO:0034242	negative regulation of syncytium formation by plasma membrane fusion
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060716	labyrinthine layer blood vessel development
GO:2000758	positive regulation of peptidyl-lysine acetylation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0015629	actin cytoskeleton
GO:0016605	PML body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000058794

View Gene Order

ENSBTAG00000001562

Not yet available

Pathways

NETPATH

REACTOME

REACT_24970

Factors involved in megakaryocyte development and platelet production pathway

REACT_604

Hemostasis pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q16621

TrEMBL

A8K3E0 F8W1N9

UniProt Splice Variant

Entrez Gene

4778

UniGene

Hs.75643

RefSeq

NM_001136023 NM_001261461 NM_006163 XM_005268906 XM_005268907

HUGO

HGNC:7780

OMIM

601490

CCDS

CCDS8876

HPRD

IMGT

EMBL

AC078778 AK290555 AK290564 AK313207 BC005044 BT007288 CH471054 CR450284 DQ367844 L13974 L24122 S77763

GenPept

AAA16118 AAA35612 AAB34115 AAH05044 AAP35952 ABC79302 BAF83244 BAF83253 BAG36023 CAG29280 EAW96771 EAW96772

RNA Seq Atlas

4778