InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NFE2

Summary

InnateDB Protein

IDBP-599171.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFE2

Protein Name

nuclear factor (erythroid-derived 2), 45kDa

Synonyms

NF-E2; p45;

Species

Homo sapiens

Ensembl Protein

ENSP00000439120

InnateDB Gene

IDBG-37778 (NFE2)

Protein Structure

UniProt Annotation

Function

Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron. {ECO:0000269PubMed:11154691, ECO:0000269PubMed:16287851}.

Subcellular Localization

Nucleus, PML body. Cytoplasm. Note=The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH.

Disease Associations

Tissue Specificity

Expressed in hematopoietic cells and also in colon and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0047485	protein N-terminus binding
GO:0050699	WW domain binding

Biological Process

GO:0006337	nucleosome disassembly
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0007596	blood coagulation
GO:0007599	hemostasis
GO:0008015	blood circulation
GO:0030502	negative regulation of bone mineralization
GO:0034242	negative regulation of syncytium formation by plasma membrane fusion
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060716	labyrinthine layer blood vessel development
GO:2000758	positive regulation of peptidyl-lysine acetylation