Version 5.4
Homo sapiens Gene: LYNX1
Summary
InnateDB Gene IDBG-37826.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LYNX1
Gene Name Ly6/neurotoxin 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000180155
Encoded Proteins
IDBP-37830
Ly6/neurotoxin 1
IDBP-482429
Ly6/neurotoxin 1
IDBP-476855
Ly6/neurotoxin 1
IDBP-812373
Ly6/neurotoxin 1
IDBP-812375
Ly6/neurotoxin 1
IDBP-812378
Ly6/neurotoxin 1
IDBP-812379
Ly6/neurotoxin 1
IDBP-812381
Ly6/neurotoxin 1
IDBP-812383
Ly6/neurotoxin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Ly-6/neurotoxin gene family, a group of lymphocyte antigens that attach to the cell surface by a glycosylphosphatidylinositol anchor and have a unique structure showing conserved 8-10 cysteine residues with a characteristic spacing pattern. Functional analysis indicates that this protein is not a ligand or neurotransmitter but has the capacity to enhance nicotinic acetylcholine receptor function in the presence of acetylcholine. This gene may also play a role in the pathogenesis of psoriasis vulgaris. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:142764334-142778224
Strand Reverse strand
Band q24.3
Transcripts
ENST00000317543 ENSP00000319846
ENST00000523332 ENSP00000428713
ENST00000521396 ENSP00000428465
ENST00000522906
ENST00000615007 ENSP00000479586
ENST00000621401 ENSP00000478390
ENST00000620006 ENSP00000478402
ENST00000613110 ENSP00000481790
ENST00000614268 ENSP00000482846
ENST00000614491 ENSP00000477648
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005886 plasma membrane
GO:0030425 dendrite
GO:0031225 anchored component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9BZG9
TrEMBL E5RIY6 E5RJW2 G3V0Z9 H0YB12
UniProt Splice Variant
Entrez Gene 66004
UniGene Hs.158665 Hs.604828 Hs.609884
RefSeq NM_023946 NM_177457 NM_177458 NM_177476 NM_177477
HUGO HGNC:29604
OMIM 606110
CCDS CCDS34951 CCDS34952 CCDS6389
HPRD
IMGT
EMBL AB081838 AC083841 AF321824 AY358417 AY587277 BC032306 BQ685632 CH471162
GenPept AAK01642 AAQ88783 AAT00512 BAC56859 EAW82299 EAW82300 EAW82301 EAW82302 EAW82303 EAW82304 EAW82306
RNA Seq Atlas 66004

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca