Version 5.4
Homo sapiens Protein: LYNX1
Summary
InnateDB Protein IDBP-37830.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LYNX1
Protein Name Ly6/neurotoxin 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000319846
InnateDB Gene IDBG-37826 (LYNX1)
Protein Structure
UniProt Annotation
Function Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). In brain, isoform 2 modulates functional properties of nAChRs to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha(4)beta(2) nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha(4)beta(2) nAChRs (By similarity). Prevents plasticity in the primary visual cortex late in life (By similarity). In keratinocytes, isoform 3 delays differentiation and prevents apoptosis. {ECO:0000250, ECO:0000269PubMed:16575903}.
Subcellular Localization Isoform 1: Secreted {ECO:0000305}.Isoform 2: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. Cell projection, dendrite {ECO:0000250}. Note=Detected in Purkinje cells soma and proximal dendrites. {ECO:0000250}.Isoform 3: Secreted.
Disease Associations
Tissue Specificity Isoform 3 is expressed at highest levels in cervix and esophagus, followed by adult and fetal skin. Expressed at lower levels in brain, lung, stomach, small intestine, colon, rectum, uterus, and thymus. Not detected in spleen nor bone marrow. In the epidermis, predominantly produced by keratinocytes of the suprabasal epidermal compartment (at protein level). In attached gingiva, produced at highest levels by basal cells located in the lowermost epithelial layers (at protein level). Up- regulated 3-fold in psoriatic lesional skin. Detected in serum (at protein level). {ECO:0000269PubMed:12573258, ECO:0000269PubMed:16575903}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005886 plasma membrane
GO:0030425 dendrite
GO:0031225 anchored component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001526 CD59 antigen
PFAM PF00021
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BZG9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 66004
UniGene Hs.609884
RefSeq NP_803253
HUGO HGNC:29604
OMIM 606110
CCDS CCDS34952
HPRD 16201
IMGT
EMBL AB081838 AC083841 AF321824 AY358417 AY587277 BC032306 BQ685632 CH471162
GenPept AAK01642 AAQ88783 AAT00512 BAC56859 EAW82299 EAW82301 EAW82302 EAW82303 EAW82304 EAW82306

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca