InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP11B1

Summary

InnateDB Gene

IDBG-37905.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP11B1

Gene Name

cytochrome P450, family 11, subfamily B, polypeptide 1

Synonyms

CPN1; CYP11B; FHI; P450C11

Species

Homo sapiens

Ensembl Gene

ENSG00000160882

Encoded Proteins

IDBP-37907

cytochrome P450, family 11, subfamily B, polypeptide 1

IDBP-37911

cytochrome P450, family 11, subfamily B, polypeptide 1

IDBP-480657

cytochrome P450, family 11, subfamily B, polypeptide 1

IDBP-478161

cytochrome P450, family 11, subfamily B, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:142872356-142879846

Strand

Reverse strand

Band

q24.3

Transcripts

ENST00000292427	ENSP00000292427
ENST00000314111
ENST00000377675	ENSP00000366903
ENST00000519285	ENSP00000430144
ENST00000517471	ENSP00000428043

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0004507	steroid 11-beta-monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding

Biological Process

GO:0006700	C21-steroid hormone biosynthetic process
GO:0006704	glucocorticoid biosynthetic process
GO:0006705	mineralocorticoid biosynthetic process
GO:0006805	xenobiotic metabolic process
GO:0006955	immune response
GO:0008202	steroid metabolic process
GO:0008217	regulation of blood pressure
GO:0016125	sterol metabolic process
GO:0032342	aldosterone biosynthetic process
GO:0032870	cellular response to hormone stimulus
GO:0034651	cortisol biosynthetic process
GO:0035865	cellular response to potassium ion
GO:0042593	glucose homeostasis
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process