Version 5.4
Homo sapiens Gene: RCN1
Summary
InnateDB Gene IDBG-37942.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RCN1
Gene Name reticulocalbin 1, EF-hand calcium binding domain
Synonyms HEL-S-84; PIG20; RCAL; RCN
Species Homo sapiens
Ensembl Gene ENSG00000049449
Encoded Proteins
IDBP-37944
reticulocalbin 1, EF-hand calcium binding domain
IDBP-587442
reticulocalbin 1, EF-hand calcium binding domain
IDBP-597939
reticulocalbin 1, EF-hand calcium binding domain
IDBP-586621
reticulocalbin 1, EF-hand calcium binding domain
IDBP-591848
reticulocalbin 1, EF-hand calcium binding domain
IDBP-591700
reticulocalbin 1, EF-hand calcium binding domain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.[provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:31812391-32105755
Strand Forward strand
Band p13
Transcripts
ENST00000054950 ENSP00000054950
ENST00000506388
ENST00000530348 ENSP00000436482
ENST00000532942 ENSP00000436422
ENST00000530146
ENST00000532721 ENSP00000433249
ENST00000533898
ENST00000532474
ENST00000527337 ENSP00000436427
ENST00000531345
ENST00000528630 ENSP00000433237
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 55 [view]
Protein-Protein 55 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0043010 camera-type eye development
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005973
View Gene Order
ENSBTAG00000047362
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 5954
UniGene Hs.523576 Hs.617553 Hs.708832 Hs.710903 Hs.97887
RefSeq NM_002901
HUGO HGNC:9934
OMIM 602735
CCDS CCDS7876
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 440034 5954

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca