Version 5.4
Homo sapiens Gene: DDX28
Summary
InnateDB Gene IDBG-37948.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDX28
Gene Name DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000182810
Encoded Proteins
IDBP-37950
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is intronless. It encodes an RNA-dependent ATPase. The encoded protein is localized in the mitochondria and the nucleus, and can be transported between the mitochondria and the nucleus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:68021274-68023442
Strand Reverse strand
Band q22.1
Transcripts
ENST00000332395 ENSP00000332340
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 26 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0042645 mitochondrial nucleoid
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000045538
View Gene Order
ENSBTAG00000004290
Not yet available
Cross-References
SwissProt Q9NUL7
TrEMBL
UniProt Splice Variant
Entrez Gene 55794
UniGene Hs.458313
RefSeq NM_018380
HUGO HGNC:17330
OMIM 607618
CCDS CCDS10858
HPRD
IMGT
EMBL AC130462 AF329821 AK002144 BC024273
GenPept AAG59833 AAH24273 BAA92106
RNA Seq Atlas 55794

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca