Version 5.4
Homo sapiens Protein: DDX28
Summary
InnateDB Protein IDBP-37950.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDX28
Protein Name DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000332340
InnateDB Gene IDBG-37948 (DDX28)
Protein Structure
UniProt Annotation
Function May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity. {ECO:0000269PubMed:11350955}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11350955}. Mitochondrion {ECO:0000269PubMed:11350955}. Note=Transported between these two compartments. Nuclear localization depends on active RNA polymerase II transcription.
Disease Associations
Tissue Specificity Expressed in all tissues tested, including brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, leukocytes, colon, small intestine, ovary and prostate. {ECO:0000269PubMed:11350955}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 26 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0042645 mitochondrial nucleoid
Protein Structure and Domains
PDB ID
InterPro IPR001650 Helicase, C-terminal
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00271
PF00270
PRINTS
PIRSF
SMART SM00490
SM00487
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NUL7
PhosphoSite PhosphoSite-Q9NUL7
TrEMBL
UniProt Splice Variant
Entrez Gene 55794
UniGene Hs.458313
RefSeq NP_060850
HUGO HGNC:17330
OMIM 607618
CCDS CCDS10858
HPRD 06357
IMGT
EMBL AC130462 AF329821 AK002144 BC024273
GenPept AAG59833 AAH24273 BAA92106

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca