Version 5.4
Homo sapiens Gene: PLA2G15
Summary
InnateDB Gene IDBG-38228.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLA2G15
Gene Name phospholipase A2, group XV
Synonyms ACS; GXVPLA2; LLPL; LPLA2; LYPLA3
Species Homo sapiens
Ensembl Gene ENSG00000103066
Encoded Proteins
IDBP-38230
phospholipase A2, group XV
IDBP-379548
phospholipase A2, group XV
IDBP-379550
phospholipase A2, group XV
IDBP-753001
IDBP-747178
IDBP-749158
IDBP-751468
IDBP-752043
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:68245304-68261062
Strand Forward strand
Band q22.1
Transcripts
ENST00000219345 ENSP00000219345
ENST00000413021 ENSP00000394197
ENST00000444212 ENSP00000393610
ENST00000565744 ENSP00000454227
ENST00000562966
ENST00000565460
ENST00000568599
ENST00000568082 ENSP00000454557
ENST00000566188 ENSP00000457034
ENST00000564827 ENSP00000455461
ENST00000562449
ENST00000566978 ENSP00000457049
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004622 lysophospholipase activity
GO:0005543 phospholipid binding
GO:0008374 O-acyltransferase activity
GO:0047499 calcium-independent phospholipase A2 activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006672 ceramide metabolic process
GO:0009062 fatty acid catabolic process
GO:0046470 phosphatidylcholine metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031903
View Gene Order
ENSBTAG00000007512
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00564
Glycerophospholipid metabolism pathway
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H3BT70
UniProt Splice Variant
Entrez Gene 23659
UniGene Hs.632199
RefSeq NM_012320
HUGO HGNC:17163
OMIM 609362
CCDS CCDS10864
HPRD 07128
IMGT
EMBL AC020978
GenPept
RNA Seq Atlas 23659

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca