InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLA2G15

Summary

InnateDB Protein

IDBP-38230.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLA2G15

Protein Name

phospholipase A2, group XV

Synonyms

ACS; GXVPLA2; LLPL; LPLA2; LYPLA3;

Species

Homo sapiens

Ensembl Protein

ENSP00000219345

InnateDB Gene

IDBG-38228 (PLA2G15)

Protein Structure

UniProt Annotation

Function

Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N- acetylsphingosine and the concomitant release of a lyso- phospholipid (By similarity). May have weak lysophospholipase activity. {ECO:0000250}.

Subcellular Localization

Lysosome {ECO:0000250}. Secreted {ECO:0000269PubMed:10092508}.

Disease Associations

Tissue Specificity

Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269PubMed:10092508}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004622	lysophospholipase activity
GO:0005543	phospholipid binding
GO:0008374	O-acyltransferase activity
GO:0047499	calcium-independent phospholipase A2 activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006672	ceramide metabolic process
GO:0009062	fatty acid catabolic process
GO:0046470	phosphatidylcholine metabolic process