Version 5.4
Homo sapiens Gene: LACRT
Summary
InnateDB Gene IDBG-38240.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LACRT
Gene Name lacritin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135413
Encoded Proteins
IDBP-38242
lacritin
IDBP-598559
lacritin
IDBP-587458
lacritin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretory granules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signaling through tyrosine phosphorylation and release of calcium. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:54630811-54634895
Strand Reverse strand
Band q13.2
Transcripts
ENST00000257867 ENSP00000257867
ENST00000546721 ENSP00000448193
ENST00000547511 ENSP00000447536
ENST00000549816
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0001968 fibronectin binding
GO:0005518 collagen binding
GO:0008083 growth factor activity
GO:0043237 laminin-1 binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0008284 positive regulation of cell proliferation
GO:0019722 calcium-mediated signaling
GO:0033173 calcineurin-NFAT signaling cascade
GO:0034067 protein localization to Golgi apparatus
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051047 positive regulation of secretion
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051533 positive regulation of NFAT protein import into nucleus
GO:0070075 tear secretion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0030141 secretory granule
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9GZZ8
TrEMBL F8W0V3 H0YI00
UniProt Splice Variant
Entrez Gene 90070
UniGene Hs.307096
RefSeq NM_033277
HUGO HGNC:16430
OMIM 607360
CCDS CCDS8883
HPRD
IMGT
EMBL AC079310 AF238867 AY005150 BC062217 BC069317
GenPept AAG32949 AAG44392 AAH62217 AAH69317
RNA Seq Atlas 90070

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca