InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADCY4

Summary

InnateDB Gene

IDBG-3876.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADCY4

Gene Name

adenylate cyclase 4

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000129467

Encoded Proteins

IDBP-3878

adenylate cyclase 4

IDBP-364422

adenylate cyclase 4

IDBP-593356

adenylate cyclase 4

IDBP-594559

adenylate cyclase 4

IDBP-591965

adenylate cyclase 4

IDBP-592280

adenylate cyclase 4

IDBP-584165

adenylate cyclase 4

IDBP-588303

adenylate cyclase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:24318349-24335093

Strand

Reverse strand

Band

q12

Transcripts

ENST00000310677	ENSP00000312126
ENST00000418030	ENSP00000393177
ENST00000557056	ENSP00000450481
ENST00000555684
ENST00000554577
ENST00000554068	ENSP00000452250
ENST00000545213
ENST00000554781	ENSP00000450477
ENST00000561200
ENST00000560635
ENST00000554936
ENST00000554959
ENST00000556932	ENSP00000450843
ENST00000554674
ENST00000557099
ENST00000559167	ENSP00000453259
ENST00000558563
ENST00000558125
ENST00000561138	ENSP00000453893

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004016	adenylate cyclase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016849	phosphorus-oxygen lyase activity
GO:0046872	metal ion binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006171	cAMP biosynthetic process
GO:0006833	water transport
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007268	synaptic transmission
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009190	cyclic nucleotide biosynthetic process
GO:0034199	activation of protein kinase A activity
GO:0035556	intracellular signal transduction
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0055085	transmembrane transport
GO:0071377	cellular response to glucagon stimulus

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022220

View Gene Order

ENSBTAG00000018419

Not yet available

Pathways

NETPATH

REACTOME

REACT_15530

PKA activation pathway

REACT_15497

PKA-mediated phosphorylation of CREB pathway

REACT_9000

Calmodulin induced events pathway

REACT_9053

CaM pathway pathway

REACT_111064

DAG and IP3 signaling pathway

REACT_147814

DAP12 signaling pathway

REACT_147694

DAP12 interactions pathway

REACT_24023

Vasopressin regulates renal water homeostasis via Aquaporins pathway

REACT_12079

PLC-gamma1 signalling pathway

REACT_12478

EGFR interacts with phospholipase C-gamma pathway

REACT_9417

Signaling by EGFR pathway

REACT_19231

G alpha (i) signalling events pathway

REACT_19327

G alpha (s) signalling events pathway

REACT_19333

G alpha (z) signalling events pathway

REACT_15312

Adenylate cyclase activating pathway pathway

REACT_15333

Adenylate cyclase inhibitory pathway pathway

REACT_15426

PLC beta mediated events pathway

REACT_15295

Opioid Signalling pathway

REACT_115720

PLCG1 events in ERBB2 signaling pathway

REACT_115755

Signaling by ERBB2 pathway

REACT_21310

Phospholipase C-mediated cascade pathway

REACT_9470

Signaling by FGFR pathway

REACT_17025

Downstream signal transduction pathway

REACT_16888

Signaling by PDGF pathway

REACT_25031

GABA B receptor activation pathway

REACT_1946

PKA activation in glucagon signalling pathway

REACT_1665

Glucagon signaling in metabolic regulation pathway

REACT_1505

Integration of energy metabolism pathway

REACT_120736

Signaling by FGFR in disease pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_11061

Signalling by NGF pathway

REACT_228134

Signaling by Hedgehog pathway

REACT_115871

Signaling by EGFR in Cancer pathway

REACT_21272

Downstream signaling of activated FGFR pathway

REACT_13685

Neuronal System pathway

REACT_14797

Signaling by GPCR pathway

REACT_6802

Innate Immune System pathway

REACT_25199

GABA receptor activation pathway

REACT_25330

Activation of GABAB receptors pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_267634

Hedgehog 'off' state pathway

REACT_15526

G-protein mediated events pathway

REACT_6900

Immune System pathway

REACT_12056

NGF signalling via TRKA from the plasma membrane pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_15370

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

REACT_111217

Metabolism pathway

REACT_25282

Inhibition of adenylate cyclase pathway pathway

REACT_15307

Ca-dependent events pathway

REACT_23887

Aquaporin-mediated transport pathway

REACT_116125

Disease pathway

KEGG

hsa04912

GnRH signaling pathway pathway

hsa04540

Gap junction pathway

hsa00230

Purine metabolism pathway

hsa04742

Taste transduction pathway

hsa04020

Calcium signaling pathway pathway

hsa04916

Melanogenesis pathway

hsa04270

Vascular smooth muscle contraction pathway

hsa04062

Chemokine signaling pathway pathway

hsa04914

Progesterone-mediated oocyte maturation pathway

hsa05414

Dilated cardiomyopathy pathway

hsa04114

Oocyte meiosis pathway

hsa04971

Gastric acid secretion pathway

hsa04972

Pancreatic secretion pathway

hsa04970

Salivary secretion pathway

hsa04976

Bile secretion pathway

INOH

INOH website

GPCR Adenosine A2A receptor signaling pathway pathway

INOH website

Purine nucleotides nucleosides metabolism pathway

INOH website

GPCR signaling pathway

PID NCI

Cross-References

SwissProt

Q8NFM4

TrEMBL

H0YLM0 H0YN72 Q86TZ7 Q96KY6

UniProt Splice Variant

Entrez Gene

196883

UniGene

Hs.443428

RefSeq

NM_001198568 NM_001198592 NM_139247

HUGO

HGNC:235

OMIM

600292

CCDS

CCDS9627

HPRD

11614

IMGT

EMBL

AF497516 AK056745 AK122714 AL096870 BC015982 BC117473 BC117475 BX248285 CH471078

GenPept

AAH15982 AAI17474 AAI17476 AAM94373 BAB71270 BAG53686 CAD62613 EAW66023 EAW66026 EAW66027

RNA Seq Atlas

196883