Version 5.4
Homo sapiens Gene: CD63
Summary
InnateDB Gene IDBG-38974.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD63
Gene Name CD63 molecule
Synonyms LAMP-3; ME491; MLA1; OMA81H; TSPAN30
Species Homo sapiens
Ensembl Gene ENSG00000135404
Encoded Proteins
IDBP-38976
CD63 molecule
IDBP-377287
CD63 molecule
IDBP-590199
CD63 molecule
IDBP-587145
CD63 molecule
IDBP-586333
CD63 molecule
IDBP-586571
CD63 molecule
IDBP-584123
CD63 molecule
IDBP-590537
CD63 molecule
IDBP-594685
CD63 molecule
IDBP-587465
CD63 molecule
IDBP-602041
CD63 molecule
IDBP-586568
CD63 molecule
IDBP-584164
CD63 molecule
IDBP-595743
CD63 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18930046
Forms a complex with ELANE (neutrophil elastase 2) and plays a role in the targeting of ELANE to primary granules in neutrophils
Entrez Gene
Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:55725323-55729707
Strand Reverse strand
Band q13.2
Transcripts
ENST00000257857 ENSP00000257857
ENST00000420846 ENSP00000393502
ENST00000548898 ENSP00000447938
ENST00000548117
ENST00000552067 ENSP00000449684
ENST00000548160 ENSP00000449654
ENST00000546939 ENSP00000447356
ENST00000552692 ENSP00000449337
ENST00000549117 ENSP00000447730
ENST00000550050 ENSP00000449435
ENST00000552754 ENSP00000446807
ENST00000550776 ENSP00000448091
ENST00000555199
ENST00000552164 ENSP00000449281
ENST00000551173 ENSP00000446752
ENST00000546457 ENSP00000450191
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002092 positive regulation of receptor internalization
GO:0002576 platelet degranulation
GO:0007160 cell-matrix adhesion
GO:0007596 blood coagulation
GO:0015031 protein transport
GO:0016477 cell migration
GO:0030168 platelet activation
GO:0034613 cellular protein localization
GO:0035646 endosome to melanosome transport
GO:0043473 pigmentation
GO:0045087 innate immune response (InnateDB)
GO:0048757 pigment granule maturation
GO:0050931 pigment cell differentiation
GO:1900746 regulation of vascular endothelial growth factor signaling pathway
GO:2000680 regulation of rubidium ion transport
GO:2001046 positive regulation of integrin-mediated signaling pathway
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0031088 platelet dense granule membrane
GO:0031226 intrinsic component of plasma membrane
GO:0031902 late endosome membrane
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
GO:0097487 multivesicular body, internal vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025351
View Gene Order
ENSBTAG00000011931
Not yet available
Pathways
NETPATH
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt P08962
TrEMBL A0A024RB05 C9JV86 F8VNT9 F8VV56 F8VWK8 F8W022
UniProt Splice Variant
Entrez Gene 967
UniGene Hs.613137
RefSeq NM_001780 NM_001257389 NM_001257390 NM_001257391 NM_001257392 NM_001257400 NM_001257401 NM_001267698
HUGO HGNC:1692
OMIM 155740
CCDS CCDS8890 CCDS58242 CCDS58243
HPRD 01121
IMGT
EMBL AC009779 AF508304 AK311893 BC002349 BC013017 BT007073 BT020137 BT020138 CH471054 CR542096 M58485 M59907 S93788 X07982 X62654
GenPept AAA63235 AAB21617 AAH02349 AAH13017 AAM34259 AAP35736 AAV38939 AAV38940 BAG34834 CAA30792 CAA44519 CAG46893 EAW96827 EAW96828 EAW96829
RNA Seq Atlas 967

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca