Version 5.4
Mus musculus Gene: Cd63
Summary
InnateDB Gene IDBG-198573.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd63
Gene Name CD63 antigen
Synonyms C75951; ME491; Tspan30
Species Mus musculus
Ensembl Gene ENSMUSG00000025351
Encoded Proteins
IDBP-198575
CD63 antigen
IDBP-271324
CD63 antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18930046
[Homo sapiens] Forms a complex with ELANE (neutrophil elastase 2) and plays a role in the targeting of ELANE to primary granules in neutrophils
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135404:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:128908919-128912816
Strand Forward strand
Band D3
Transcripts
ENSMUST00000026407 ENSMUSP00000026407
ENSMUST00000105229 ENSMUSP00000100862
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002092 positive regulation of receptor internalization
GO:0007160 cell-matrix adhesion
GO:0015031 protein transport
GO:0016477 cell migration
GO:0034613 cellular protein localization
GO:0035646 endosome to melanosome transport
GO:0043473 pigmentation
GO:0048757 pigment granule maturation
GO:0050931 pigment cell differentiation
GO:1900746 regulation of vascular endothelial growth factor signaling pathway
GO:2000680 regulation of rubidium ion transport
GO:2001046 positive regulation of integrin-mediated signaling pathway
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0031226 intrinsic component of plasma membrane
GO:0031902 late endosome membrane
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
GO:0097487 multivesicular body, internal vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000135404
View Gene Order
ENSBTAG00000011931
Not yet available
Pathways
NETPATH
REACTOME
REACT_230203
Platelet degranulation pathway
REACT_224553
Hemostasis pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
KEGG
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
REACT_202252
Platelet degranulation pathway
REACT_212196
Hemostasis pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_212308
Response to elevated platelet cytosolic Ca2+ pathway
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt P41731
TrEMBL Q549D0 Q8BT06
UniProt Splice Variant
Entrez Gene 12512
UniGene Mm.405981 Mm.413564
RefSeq NM_001042580 NM_001282966 NM_007653
OMIM
CCDS CCDS24297
HPRD
IMGT
MGI ID MGI:99529
MGI Symbol Cd63
EMBL AF159427 AK028220 AK146618 AK151702 AK151963 AK152072 AK152372 AK159875 AK163785 AK166543 AK166766 AK170344 BC008108 BC012212 BC083161 CH466578 CT010179 D16432
GenPept AAD43135 AAH08108 AAH12212 AAH83161 BAA03904 BAC25821 BAE27307 BAE30625 BAE30834 BAE30925 BAE31162 BAE35447 BAE37493 BAE38843 BAE39004 BAE41734 CAJ18387 EDL24631
RNA Seq Atlas 12512

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca