Version 5.4
Homo sapiens Gene: CAPRIN1
Summary
InnateDB Gene IDBG-38977.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAPRIN1
Gene Name cell cycle associated protein 1
Synonyms GPIAP1; GPIP137; GRIP137; M11S1; p137GPI; RNG105
Species Homo sapiens
Ensembl Gene ENSG00000135387
Encoded Proteins
IDBP-38979
cell cycle associated protein 1
IDBP-38989
cell cycle associated protein 1
IDBP-594471
cell cycle associated protein 1
IDBP-590658
cell cycle associated protein 1
IDBP-583546
cell cycle associated protein 1
IDBP-585652
cell cycle associated protein 1
IDBP-809866
cell cycle associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25784705
The G3BP1-CAPRIN1-PRKRA complex represents a new mode of PRKRA activation and links stress responses with innate immune activation through PRKRA without a requirement for foreign double-stranded RNA pattern recognition.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:34051683-34101156
Strand Forward strand
Band p13
Transcripts
ENST00000341394 ENSP00000340329
ENST00000389645 ENSP00000374296
ENST00000526477
ENST00000528856
ENST00000534042
ENST00000534825 ENSP00000431373
ENST00000532820 ENSP00000434150
ENST00000530820 ENSP00000434204
ENST00000529307 ENSP00000431581
ENST00000526494
ENST00000532755
ENST00000533641
ENST00000530008
ENST00000533657
ENST00000528948
ENST00000531668
ENST00000533562
ENST00000618582 ENSP00000483169
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0017148 negative regulation of translation
GO:0045087 innate immune response (InnateDB)
GO:0050775 positive regulation of dendrite morphogenesis
GO:0061003 positive regulation of dendritic spine morphogenesis
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005887 integral component of plasma membrane
GO:0010494 cytoplasmic stress granule
GO:0016020 membrane
GO:0030425 dendrite
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027184
View Gene Order
ENSBTAG00000016744
Not yet available
Cross-References
SwissProt Q14444
TrEMBL E9PLA9 G3V153
UniProt Splice Variant
Entrez Gene 4076
UniGene Hs.471818 Hs.595571 Hs.601307 Hs.626417 Hs.717895
RefSeq NM_005898 NM_203364
HUGO HGNC:6743
OMIM 601178
CCDS CCDS31453 CCDS31454
HPRD
IMGT
EMBL AC090469 BC001731 BK001101 BK001104 BR000867 CH471064 X89572 Z48042
GenPept AAH01731 CAA61751 CAA88096 DAA01118 DAA01121 EAW68177 EAW68178 EAW68179 EAW68180 FAA00692
RNA Seq Atlas 4076

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca