InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PPP2R3B

Summary

InnateDB Gene

IDBG-39003.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP2R3B

Gene Name

protein phosphatase 2, regulatory subunit B'', beta

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000167393

Encoded Proteins

IDBP-39005

protein phosphatase 2, regulatory subunit B'', beta

IDBP-39011

protein phosphatase 2, regulatory subunit B'', beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:333963-386955

Strand

Reverse strand

Band

p22.33

Transcripts

ENST00000381625	ENSP00000371038
ENST00000390665	ENSP00000375080
ENST00000445792
ENST00000479438
ENST00000477110
ENST00000468169
ENST00000484364
ENST00000477636
ENST00000496630
ENST00000475859

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008601	protein phosphatase type 2A regulator activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006470	protein dephosphorylation
GO:0007050	cell cycle arrest
GO:0050790	regulation of catalytic activity